Publication details
Neuroonkologické aspekty u nemocných s farmakorezistentní epilepsií
| Title in English | Neurooncological aspects in patiens with pharmacoresistant epilepsy |
|---|---|
| Authors | |
| Year of publication | 2015 |
| Type | Article in Periodical |
| Magazine / Source | Onkologie |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | pharmacoresistant epilepsy; low grade glioma; hemimegalencephaly; glioblastoma multiforme |
| Attached files | |
| Description | Malformations of cortical development and benign brain tumors are frequent causes of long lasting pharmacoresistant epilepsy in paediatric and adult patients. Such patients are surgically treated and subsequently followed in epileptosurgical centers. Tumor upgrading in patients with pharmacoresistant epilepsy is only rarely encountered and the development of malignant brain tumor in a patient with malformation of cortical development is an exception. The aim of the paper is to present two cases of patients suffering from intractable epilepsy with unexpected development of malignant brain tumor. There was upgrading of low grade glioma (verified by repeated biopsy sampling) in one patient with chronic epilepsy with final diagnosis glioblastoma multiforme. An exceptional development of glioblastoma in hemimegalencephalic hemisphere was described in the second patient. |