Publication details

MicroRNAs in urine are not biomarkers of multiple myeloma

Authors

SEDLAŘÍKOVÁ Lenka BEŠŠE Lenka NOVOSADOVÁ Soňa KUBACZKOVÁ Veronika RADOVÁ Lenka STANÍK Michal KREJČÍ Marta HÁJEK Roman ŠEVČÍKOVÁ Sabina

Year of publication 2015
Type Article in Periodical
Magazine / Source Journal of Negative Results in BioMedicine
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1186/s12952-015-0035-7
Field Oncology and hematology
Keywords MicroRNAs; urine; biomarkers; multiple myeloma
Attached files
Description Background: In this study, we aimed to identify microRNA from urine of multiple myeloma patients that could serve as a biomarker for the disease. Results: Analysis of urine samples was performed using Serum/Plasma Focus PCR MicroRNA Panel (Exiqon) and verified using individual TaqMan miRNA assays for qPCR. We found 20 deregulated microRNA (p < 0.05); for further validation, we chose 8 of them. Nevertheless, only differences in expression levels of miR-22-3p remained close to statistical significance. Conclusions: Our preliminary results did not confirm urine microRNA as a potential biomarker for multiple myeloma.

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