Publication details

Effects of Atorvastatin (80 mg) Therapy on Quantity of Epicardial Adipose Tissue in Patients Undergoing Pulmonary Vein Isolation for Atrial Fibrillation

Authors

SOUČEK Filip COVASSIN Naima SINGH Prachi RŮŽEK Lukáš KÁRA Tomáš SULEIMAN Mahmoud LERMAN Amir KOESTLER Celeste FRIEDMAN Paul A. LOPEZ-JIMENEZ Francisco SOMERS Virend K.

Year of publication 2015
Type Article in Periodical
Magazine / Source American Journal of Cardiology
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1016/j.amjcard.2015.07.067
Field Cardiovascular diseases incl. cardiosurgery
Keywords CARDIOVASCULAR RISK; STATINS; HEART; DIFFERENTIATION; METAANALYSIS; CHOLESTEROL; 3T3-L1; TRIALS; CELLS; FAT
Description Epicardial adipose tissue (EAT) has been recognized as a sensitive marker of cardiometabolic risk. Recent evidence suggests efficacy of long-term statin therapy in reducing EAT in patients with coronary artery disease. Whether short-term statin therapy is associated with changes in the volume of EAT is currently unknown. A cohort of patients with atrial fibrillation who underwent pulmonary vein isolation were randomized to receive either 80 mg/day of atorvastatin (n = 38, 32 men, age 56 11 years) or placebo (n = 41, 33 men, age 56 +/- 10 years) for a 3-month period. EAT volume was assessed by cardiac computed tomography at baseline and at follow-up. Patients randomized to statin treatment exhibited a modest but significant decrease in median EAT volume (baseline vs follow-up: 92.3 cm(3) [62.0 to 133.3] vs 86.9 cm(3) [64.1 to 124.8], p < 0.05), whereas median EAT remained unchanged in the placebo group (81.9 cm(3) [55.5 to 110.9] vs 81.3 cm(3) [57.1 to 110.5], p = NS). Changes in median systemic inflammatory markers and lipid profile were also seen with statin treatment: C-reactive protein (2.4 mg/L [0.7 to 3.7] vs 1.1 mg/L [0.5 to 2.7], p < 0.05), total cholesterol (186 mg/dL [162.5 to 201] vs 123 mg/dL [99 to 162.5], p < 0.001), and low-density lipoprotein cholesterol (116 mg/dL [96.5 to 132.5] Vs 56 [40.5 to 81] mg/dL, p < 0.001) diminished, whereas median body mass index did not change (27.8 kg/m(2) [25 to 30] versus 27.6 kg/m(2) [25.7 to 30.5], p = NS). No variations occurred in the placebo group. In conclusion, short-term intensive statin therapy significantly reduced the volume of EAT in patients with atrial fibrillation. (C) 2015 Elsevier Inc. All rights reserved.

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