Publication details

Karyotype complexity and prognosis in acute myeloid leukemia

Authors	STÖLZEL F. MOHR B. KRAMER M. OELSCHLÄGEL U. BOCHTLER T. BERDEL W.E. KAUFMANN M. BALDUS C.D. SCHÄFER-ECKART K. STUHLMANN R. EINSELE H. KRAUSE S.W. SERVE H. HÄNEL M. HERBST R. NEUBAUER A. SOHLBACH K. MAYER Jiří MIDDEKE J.M. PLATZBECKER U. SCHAICH M. KRÄMER A. RÖLLIG C. SCHETELIG J. BORNHÄUSER M. EHNINGER G.
Year of publication	2016
Type	Article in Periodical
Magazine / Source	Blood Cancer Journal
MU Faculty or unit	Faculty of Medicine
Citation
Doi	http://dx.doi.org/10.1038/bcj.2015.114
Field	Oncology and hematology
Keywords	HEMATOPOIETIC-CELL TRANSPLANTATION; PROSPECTIVE AML96 TRIAL; EUROPEAN LEUKEMIANET; MONOSOMAL KARYOTYPE; RECOMMENDATIONS; IMPACT; CLASSIFICATION; ABNL(17P); DIAGNOSIS; SYSTEM
Attached files	EL_1333758.pdf
Description	A complex aberrant karyotype consisting of multiple unrelated cytogenetic abnormalities is associated with poor prognosis in patients with acute myeloid leukemia (AML). The European Leukemia Net classification and the UK Medical Research Council recommendation provide prognostic categories that differ in the definition of unbalanced aberrations as well as the number of single aberrations. The aim of this study on 3526 AML patients was to redefine and validate a cutoff for karyotype complexity in AML with regard to adverse prognosis. Our study demonstrated that (1) patients with a pure hyperdiploid karyotype have an adverse risk irrespective of the number of chromosomal gains, (2) patients with translocation t(9;11)(p21~22;q23) have an intermediate risk independent of the number of additional aberrations, (3) patients with greater than or equal to4 abnormalities have an adverse risk per se and (4) patients with three aberrations in the absence of abnormalities of strong influence (hyperdiploid karyotype, t(9;11)(p21~22;q23), CBF-AML, unique adverse-risk aberrations) have borderline intermediate/adverse risk with a reduced overall survival compared with patients with a normal karyotype.