Publication details

Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis

Authors

IZAKOVIČOVÁ HOLLÁ Lydie VALOVÁ Simona BOŘILOVÁ LINHARTOVÁ Petra BÁRTOVÁ Jiřina PETANOVÁ Jitka KUKLÍNEK Pavel FASSMANN Antonín

Year of publication 2017
Type Article in Periodical
Magazine / Source Journal of Oral Pathology & Medicine
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1111/jop.12594
Field Genetics and molecular biology
Keywords IL-1; IL-6; gene polymorphism; aphthous stomatitis; case-control study
Description Background Recurrent aphthous stomatitis (RAS) is one of the most common oral chronic ulcerative disease in which proinflammatory cytokines such as interleukin 1 (IL-1) and interleukin 6 (IL-6) are thought to play an important role. The aim of this study was to investigate the possible association between polymorphisms in the IL-1 cytokine family, IL-6 or its receptor and RAS in the Czech population. Methods A total of 248 subjects, 184 healthy controls and 64 patients with RAS were genotyped for IL-1A-889C>T, IL-1B-511C>T, IL-1B+3953C>T, IL-1RN86 bp variable number of tandem repeats (VNTR) in intron 2, IL-6-597G>A, IL-6-572G>C, IL-6-174G>C and IL-6R+48992A>C by polymerase chain reaction (PCR) methods. Results No significant differences between investigated polymorphisms in healthy subjects and patients with RAS were detected (P>0.05). In addition, complex analysis also revealed similar IL-1 or IL-6 haplotype frequencies between both groups (P>0.05). Conclusions In conclusion, IL-1 and IL-6 or its receptor gene variants cannot be used as markers for identification of Czech patients with increased risk of recurrent aphthous stomatitis.
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