Publication details

Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease

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Authors

RAUDENSKÁ Martina DVOŘÁKOVÁ Veronika PÁCAL Lukáš CHALÁSOVÁ Katarína KRATOCHVÍLOVÁ Monika GUMULEC Jaromír RUTTKAY-NEDECKY B. ZITKA O. KAŇKOVÁ Kateřina ADAM V. MASAŘÍK Michal

Year of publication 2017
Type Article in Periodical
Magazine / Source JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1002/jbt.21891
Field Biochemistry
Keywords diabetes; diabetic kidney disease; heavy metals; metallothionein; oxidative stress
Description Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione) were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin. Single nucleotide polymorphism (rs28366003) in MT gene was detected. Antiradical capacity, conjugated bilirubin, and copper were significantly increased in diabetics, whereas MT and glutathione were decreased. Genotype AA of rs28366003 was associated with higher zinc levels in the diabetic group. The studied parameters were not influenced by renal function. This is the first study comprehensively investigating differences in MT and metals relevant to oxidative stress in T2DM. Ascertained differences indicate increased oxidative stress in T2DM accompanied by abnormalities in non-enzymatic antioxidant defense systems.
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