Publication details

Betablokátory v registru chronického srdečního selhání FAR NHL

Title in English Beta-blockers in chronic heart failure as recorded in the FAR NHL registr
Authors

LÁBR Karel ŠPINAR Jindřich PAŘENICA Jiří ŠPINAROVÁ Lenka MÁLEK F. ŠPINAROVÁ Monika LUDKA Ondřej JARKOVSKÝ Jiří BENEŠOVÁ Klára LÁBROVÁ Růžena

Year of publication 2017
Type Article in Periodical
Magazine / Source Kardiologická revue - Interní medicína
MU Faculty or unit

Faculty of Medicine

Citation
Field Cardiovascular diseases incl. cardiosurgery
Keywords adrenergic beta-antagonists; heart failure; pro-brain natriuretic peptide; blood pressure
Description Background: Beta-blockers (BB) and angiotensin-converting-enzyme inhibitors (ACE-I) or angiotensin receptor blockers (ARB) are part of the first-line treatment of heart failure with reduced ejection fraction (HFrEF), leading to decreased morbidity and mortality. Methods: The data were collected from the Pharmacology and l Neurohumoral Activation Registry (FAR NHL). Patients with left ventricle ejection fraction (LV EF) under 50% who were stable for at least one month were included. Results: A total of 1,100 patients were included, median age was 65 years, 80.8% were male. Of all patients, 20% received low dose (LD), 57% medium dose (MD) and 17% high dose (HD). Of these, 6.2% of patients were not treated with BBs at all. The higher the blood pressure (BP; LD 124/77; MD 129/80; HD 132/82 mm Hg, p < 0.001), LV EF (LD 29.5; MD 30.5; HD 32.0%; p = 0.003), creatinine clearance rate (CrCl; LD 78.7; MD 87.8; HD 91.1 ml/min; p = 0.001) or body weight (LD 83.2; MD 88.7; HD 93.5 kg; p < 0.001) was, the higher the dose of BB they received. The lower the NT-proBNP level was, the higher the dose of BB they received (LD 767; MD 456; HD 314 pg/ml; p < 0.001). There was no difference in prescription of BB depending on the presence of atrial fibrillation (AF). Patients with AF were more often treated with digoxin or a combination of digoxin and BB than patients without AF (p < 0.001). Summary: Nearly 94% of HFrEF patients received BB, but only 17% received the target dose of BB. Ninety-nine % of patients treated with BB received one of the drugs recommended by the ESC Guidelines. The more severe the illness was, as expressed by lower BP, CrCl, LV EF, body weight and higher NT-proBNP, the lower the dose of BB the patients received and tolerated.
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