Publication details

Intralipid infusion in paediatric patient with quetiapine and lamotrigine intoxication

Authors

KLUČKA Jozef JUŘENČÁK Tomáš KOSINOVÁ Martina ŠTOURAČ Petr KRATOCHVÍL Milan SEDLÁČKOVÁ Yvona NAVRÁTIL Tomáš PELCLOVÁ Daniela JABANDŽIEV Petr

Year of publication 2019
Type Article in Periodical
Magazine / Source Monatshefte fur Chemie
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.1007/s00706-019-02423-5
Doi http://dx.doi.org/10.1007/s00706-019-02423-5
Keywords Antipsychotic drug intoxication; Life-threatening arrhythmia; Lipid resuscitation; Paediatric patient
Description We present a case of the acute intoxication of a 17-year-old patient after ingestion of 6 g of quetiapine in combination with 1 g of lamotrigine. Due to the severe tachycardia, hypertension, and prolonged QTc without improvement after standard treatment, the patient was treated with Intralipid 20% intravenous infusion recommended by the Toxicologic Information Centre. After lipid infusion, the QTc rapidly normalised and tachycardia resolved to sinus rhythm. The patient was transferred to psychiatry intensive care on the third day after admission. [GRAPHICS] .
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