Publication details

Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure?

Authors

MUNSTER Lukas FOJTŮ Michaela CAPAKOVA Zdenka MUCHOVA Monika MUSILOVA Lenka VACULOVIČ Tomáš BALVAN Jan KURITKA Ivo MASAŘÍK Michal VICHA Jan

Year of publication 2021
Type Article in Periodical
Magazine / Source Carbohydrate Polymers
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.sciencedirect.com/science/article/pii/S0144861720317355?via%3Dihub
Doi http://dx.doi.org/10.1016/j.carbpol.2020.117562
Keywords Drug delivery; Cellulose; Dextran; Dextrin; Sodium hyaluronate; Selective oxidation
Description Study provides an in-depth analysis of the structure-function relationship of polysaccharide anticancer drug carriers and points out benefits and potential drawbacks of differences in polysaccharide glycosidic bonding, branching and drug binding mode of the carriers. Cellulose, dextrin, dextran and hyaluronic acid have been regioselectively oxidized to respective dicarboxylated derivatives, allowing them to directly conjugate cisplatin, while preserving their major structural features intact. The structure of source polysaccharide has crucial impact on conjugation effectiveness, carrier capacity, drug release rates, in vitro cytotoxicity and cellular uptake. For example, while branched structure of dextrin-based carrier partially counter the undesirable initial burst release, it also attenuates the cellular uptake and the cytotoxicity of carried drug. Linear polysaccharides containing beta-(1 -> 4) glycosidic bonds and oxidized at C2 and C3 (cellulose and hyaluronate) have the best overall combination of structural features for improved drug delivery applications including potentiation of the cisplatin efficacy towards malignances.
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