Publication details

Urine immunofixation negativity is not necessary for complete response in intact immunoglobulin multiple myeloma: Retrospective real-world confirmation

Authors

RADOCHA Jakub JELINEK Tomas POUR Luděk SPICKA Ivan MINARIK Jiri POPKOVA Tereza JUNGOVA Alexandra PAVLICEK Petr BROŽOVÁ Lucie ŠTORK Martin SEDLAK Frantisek KRHOVSKA Petra MAISNAR Vladimir HEINDORFER Adriana SYKORA Michal WROBEL Marek MIKULA Peter KESSLER Petr ULLRYCHOVA Jana HAJEK Roman

Year of publication 2021
Type Article in Periodical
Magazine / Source International Journal of Laboratory Hematology
MU Faculty or unit

Faculty of Medicine

Citation
Web https://onlinelibrary.wiley.com/doi/10.1111/ijlh.13460
Doi http://dx.doi.org/10.1111/ijlh.13460
Keywords Urine immunofixation negativity; intact immunoglobulin multiple myeloma
Description The definition of complete disease response (CR) in multiple myeloma (MM) continues to be reevaluated. The last widely accepted model of response assessment was proposed by the International Myeloma Working Group (IMWG) in 2016.1 Urine immunofixation (uIFE), one of the CR parameters, is being frequently omitted from CR evaluation in routine clinical practice. Patients with missing uIFE are then reported as having very good partial response (VGPR).2 It has been recently suggested in retrospective analysis by Lahuerta et al3 that patients with intact immunoglobulin myeloma (IIMM) who lack uIFE examination present with the very same prognosis as the patients with negative uIFE and therefore uIFE might not be necessary for CR definition in such patients.

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