Publication details

Enhancing cisplatin anticancer effectivity and migrastatic potential by modulation of molecular weight of oxidized dextran carrier

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Authors

MUNSTER L. FOJTŮ Michaela MUCHOVA M. LATECKA F. KACEROVA S. CAPAKOVA Z. JURIŇÁKOVÁ Tamara KURITKA I. MASAŘÍK Michal VICHA J.

Year of publication 2021
Type Article in Periodical
Magazine / Source Carbohydrate Polymers
MU Faculty or unit

Faculty of Medicine

Citation
Web https://reader.elsevier.com/reader/sd/pii/S0144861721008481?token=6B980116FFE89BE9644D630E5871F9E438C2A85EC19DD545C3ABE52B8108EA349F2BD805D3531CE612288A0775CE71A2&originRegion=eu-west-1&originCreation=20220124064804
Doi http://dx.doi.org/10.1016/j.carbpol.2021.118461
Keywords Drug-delivery; Dextran; Periodate oxidation; Molecular weight; Cisplatin; Carrier
Description The molecular weight (M-w) of dextran derivatives, such as regioselectively oxidized dicarboxydextran (DXA), is greatly influencing their faith in an organism, which could be possibly used to improve anticancer drug delivery. Here we present a modified method of sulfonation-induced chain scission allowing direct and accurate control over the M-w of DXA without increasing its polydispersity. Prepared DXA derivatives (M-w = 10-185 kDa) have been conjugated to cisplatin and the M-w of the carrier found to have a significant impact on cisplatin release rates, in vitro cytotoxicity, and migrastatic potential. Conjugates with the high-M-w DXA showed particularly increased anticancer efficacy. The best conjugate was four times more effective against malignant prostatic cell lines than free cisplatin and significantly inhibited the ovarian cancer cell migration. This was traced to the characteristics of spontaneously formed cisplatin-crosslinked DXA nanogels influenced by M-w of DXA and amount of loaded cisplatin.
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