Publication details

Malignant Hyperthermia in PICU-From Diagnosis to Treatment in the Light of Up-to-Date Knowledge

Authors

KLINCOVÁ Martina ŠTĚPÁNKOVÁ Dagmar SCHRÖDEROVÁ Ivana KLABUSAYOVÁ Eva ŠTOURAČ Petr

Year of publication 2022
Type Article in Periodical
Magazine / Source Children-Basel
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.mdpi.com/2227-9067/9/11/1692
Doi http://dx.doi.org/10.3390/children9111692
Keywords malignant hyperthermia; children; PICU; critical; triggers; sevoflurane; succinylcholine; dantrolene; cooling; RYR1
Description Malignant Hyperthermia (MH) is a rare, hereditary, life-threatening disease triggered by volatile anesthetics and succinylcholine. Rarely, MH can occur after non-pharmacological triggers too. MH was detected more often in children and young adults, which makes this topic very important for every pediatric specialist, both anesthesiologists and intensivists. MH crisis is a life-threatening severe hypermetabolic whole-body reaction. Triggers of MH are used in pediatric intensive care unit (PICU) as well, volatile anesthetics in difficult sedation, status asthmaticus or epilepticus, and succinylcholine still sometimes in airway management. Recrudescence or delayed onset of MH crisis hours after anesthesia was previously described. MH can also be a cause of rhabdomyolysis and hyperpyrexia in the PICU. In addition, patients with neuromuscular diseases are often admitted to PICU and they might be at risk for MH. The most typical symptoms of MH are hypercapnia, tachycardia, hyperthermia, and muscle rigidity. Thinking of the MH as the possible cause of deterioration of a patient's clinical condition is the key to early diagnosis and treatment. The sooner the correct treatment is commenced, the better patient's outcome. This narrative review article aims to summarize current knowledge and guidelines about recognition, treatment, and further management of MH in PICU.
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