Publication details

Lipoprotein Subfractions Associated with Endothelial Function in Previously Healthy Subjects with Newly Diagnosed Sleep Apnea-A Pilot Study

Authors

HLUCHANOVA Alzbeta KOLLAR Branislav KLOBUCNIKOVA Katarina HARDONOVA Miroslava PODDANY Michal ZITNANOVA Ingrid DVORAKOVA Monika KONARIKOVA Katarina TEDLA Miroslav URÍK Milan KLAIL Pavel SKOPEK Petr TURCANI Peter SIARNIK Pavel

Year of publication 2023
Type Article in Periodical
Magazine / Source LIFE-BASEL
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.mdpi.com/2075-1729/13/2/441
Doi http://dx.doi.org/10.3390/life13020441
Keywords lipoprotein subfractions; obstructive sleep apnea; polysomnography
Description Background: Obstructive sleep apnea (OSA) activates several pathophysiological mechanisms which can lead to the development of vascular diseases. Endothelial dysfunction (ED) is an initial step in the development of atherosclerosis. The association between ED and OSA has been described in several studies, even in previously healthy subjects. High-density lipoproteins (HDL) were generally considered to be atheroprotective, and low-density lipoprotein (LDL) to be an atherogenic component of lipoproteins. However, recent findings suggest a pro-atherogenic role of small HDL subfractions (8-10) and LDL subfractions (3-7). This study aimed to evaluate the relationship between endothelial function and lipid subfractions in previously healthy OSA subjects. Material and Methods: We prospectively enrolled 205 subjects with sleep monitoring. Plasma levels of triacylglycerols, total cholesterol, LDL, HDL, and their subfractions were assessed. Endothelial function was determined using peripheral arterial tonometry, and reperfusion hyperemia index (RHI) was assessed. Results: Plasma levels of small and intermediate HDL subfractions have statistically significant pro-atherogenic correlations with endothelial function (p = 0.015 and p = 0.019). In other lipoprotein levels, no other significant correlation was found with RHI. In stepwise multiple linear regression analysis, small HDL (beta = -0.507, p = 0.032) was the only significant contributor in the model predicting RHI. Conclusions: In our studied sample, a pro-atherogenic role of small HDL subfractions in previously healthy subjects with moderate-to-severe OSA was proven.

You are running an old browser version. We recommend updating your browser to its latest version.

More info