Publication details

Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins

Authors

JEŠETA Michal POSPÍŠILOVÁ Anna MEKIŇOVÁ Lenka FRANZOVÁ Kateřina VENTRUBA Pavel LOUSOVÁ Eva KEMPISTY Bartosz OŽDIAN Tomáš ŽÁKOVÁ Jana CRHA Igor

Year of publication 2023
Type Article in Periodical
Magazine / Source Diagnostics
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.mdpi.com/2075-4418/13/15/2468
Doi http://dx.doi.org/10.3390/diagnostics13152468
Keywords spermatozoa; azoospermia; sperm isolation; sperm analyses
Description The compounds of seminal plasma have great potential as biomarkers of male fertility and can be used as a diagnostic tool for types of azoospermia. Azoospermia occurs in approximately 1% of the male population, and for an effective therapy of this form of male infertility, it is important to distinguish between obstructive and non-obstructive azoospermia. Proteins in seminal plasma can serve as biomarkers for diagnosing azoospermia. Considering the various types of obstructions, a combination of multiple proteins is advisable for diagnostic purposes. In this context, testicular and epididymal proteins are particularly significant, as they are specific to these tissues and typically absent in ejaculate during most obstructions. A combination of multiple biomarkers is more effective than the analysis of a single protein. This group of markers contains TEX101 and ECM1 proteins, combined detections of these two bring a diagnostic output with a high sensitivity and specificity. Similar results were observed for combined detection of TEX101 and SPAG1. The effective using of specific biomarkers from seminal plasma can significantly improve the existing approaches to diagnosis of the causes of male infertility.

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