Publication details

The effects of Fos proteins on myeloid differentiation

Authors

ZAHRADNÍČKOVÁ Eva ŠEVČÍKOVÁ Sabina SOUČEK Karel ŠMARDA Jan

Year of publication 2001
Type Article in Proceedings
Conference V. Pracovní setkání biochemiků a molekulráních biologů
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords Fos
Description The line of v-myb-transformed chicken monoblasts BM2 is a suitable model for study of myeloid differentiation. These cells proliferate in monoblastic stage and their terminal differentiation steps are blocked. We found that overexpression of v-fos and c-fos causes growth arrest of BM2 cells. To clarify this observation we performed cell cycle analysis. We found that c-Fos partially induces apoptosis while v-Fos rather affects cell cycle of BM2 cells.
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