Publication details

Drugs elevating extracellular adenosine enhance cell cycling of hematopoietic progenitor cells as inferred from the cytotoxic effects of 5-fluorouracil

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Authors

POSPÍŠIL Milan HOFER Michal VACEK Antonín NETÍKOVÁ Jaromíra HOLÁ Jiřina ZNOJIL Vladimír WEITEROVÁ Lenka

Year of publication 2001
Type Article in Periodical
Magazine / Source Experimental Hematology
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Description Our previous studies showed that the combined administration of drugs elevating extracellular adenosine, i.e., dipyridamole and adenosine monophosphate (AMP), enhanced hematopoiesis in normal mice and increased hematopoietic recovery in irradiated mice. In the present study, we have examined the possibility that these effects are due to the adenosine-induced cycling of the hematopoietic progenitor cells.
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