Publication details

A newly identified single nucleotide polymorphism in the promoter of the matrix metalloproteinase-1 gene

Authors

JURAJDA Michal MUŽÍK Jan IZAKOVIČOVÁ HOLLÁ Lydie VÁCHA Jiří

Year of publication 2002
Type Article in Periodical
Magazine / Source Molecular and Cellular Probes
MU Faculty or unit

Faculty of Medicine

Citation
Field Genetics and molecular biology
Keywords single nucleotide polymorphism; matrix metalloproteinase
Description Matrix metalloproteinase-1 (MMP-1) is a member of the matrix metalloproteinase enzyme family that degrades components of the extracellular matrix. Recent studies have demonstrated several polymorphic sites in the promoter of the MMP-1 gene. A newly identified single nucleotide polymorphism (SNP) at position -519 in the promoter region of the MMP-1 gene is reported. This polymorphism consists in a guanine to adenine substitution. A linkage between polymorphisms -519A/G and -1607 1G/2G was also studied.
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