Publication details

UVC-Protective Effect of Caffeic Acid on Normal and Transformated Human Skin Cells in Vitro

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Authors

NERADIL Jakub VESELSKA Renata SLANINA Jiri

Year of publication 2003
Type Article in Periodical
Magazine / Source Folia Biologica
MU Faculty or unit

Faculty of Medicine

Citation
Field Biochemistry
Keywords UVC; caffeic acid; UV-protective effect; alpha-tocopherol
Description Possible UVC-protective properties of caffeic acid (CA), a plant phenolic compound with antioxidant activity, were investigated on human KF1 diploid fibroblast and A431 epidermoid carcinoma cell lines. Cell populations, untreated and treated by antioxidants (CA and á-tocopherol), were irradiated by UVC at the wavelength of 254 nm and their proliferation activity was determined by the MTT-assay. Results show a strong protective effect of CA at both concentrations used (55.5 and 165.5 ěM). This protective ability is probably based on the antioxidant and scavenging activities of CA, which seems to be more efficient than á-tocopherol in protection against cytotoxic effect caused by UVC-irradiation.
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