Publication details

Role of enzymatically inactive procathepsin D in lung cancer.

Authors

VĚTVIČKA Václav VĚTVIČKOVÁ Jana BENEŠ Petr

Year of publication 2004
Type Article in Periodical
Magazine / Source Anticancer Research
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords procathepsin D; proliferation; lung cancer; invasiveness
Description Procathepsin D is over-secreted by some human cancer cells. This enzymatically inactive precursor has been established as playing an important role in the development of several types of cancer. In the present investigation, we used both the isolated human procathepsin D and a synthetic 44 amino acid peptide corresponding to the activation peptide of procathepsin D to test their effects on the proliferation of lung cancer cells. We showed that both the procathepsin D and the activation peptide act as growth factors. In parallel, we also measured the secretion of procathepsin D by lung cancer cells and compared the secretion with invasiveness through Matrigel membrane. Our findings represent the first experimental data showing the direct effects of procathepsin D and its activation peptide on growth and invasiveness of lung cancer cells.

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