Publication details
Synthesis and reactions of methyl 2-[3-(2-phenylquinazolin-4-yl)thioureido]alkanoates
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Periodical |
| Magazine / Source | ARKIVOC |
| MU Faculty or unit | |
| Citation | |
| Field | Organic chemistry |
| Keywords | Non-nucleoside RT inhibitors; quinazoline; thioureas; amino acids; imidoyl isothiocyanate; Domino-reaction; intramolecular cyclization |
| Description | Methyl 2-[3-(2-phenylquinazolin-4-yl)thioureido]alkanoates bearing an amino acid ester residue were prepared by a novel three step sequential reaction of N-(2-cyanophenyl)benzimidoyl isothioyanate with amino acid methyl ester hydrochlorides. Some chemoselective reactions of methyl 2-[3-(2-phenylquinazolin-4-yl)thioureido]alkanoates with alkyl halides were studied. |
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