Publication details

EXPRESE TRANSKRIPČNÍHO FAKTORU NFAT1 ZVYŠUJE CITLIVOST MONOBLASTŮ BM2 KE KYSELINĚ RETINOVÉ

Title in English Overexpression of transcription factor NFAT1 increases sensitivity of monoblasts BM2 to retinoic acid
Authors

TRČKA Filip KUZIAKOVÁ Kateřina BENEŠ Petr ŠMARDA Jan

Year of publication 2009
Type Article in Proceedings
Conference XIII. Setkání biochemiků a molekulárních biologů
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords differentiation; NFAT1; retinoic acid; monoblast
Description NFAT is a nuclear protein that undergoes activation in myelomonoctic cells and plays a key role in regulation of osteoclastogenesis. In this study we showed that BM2 monoblasts with increased level of NFAT expression become more sensitive to retinoic acid. These cells respond to the retinoic acid treatment by growth arrest, changes in cellular morphology, increased phagocytic activity and production of oxygen radicals.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info