Publication details
Solving the shugoshin puzzle
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | Trends in genetics |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCY-4S69S1J-1&_user=835458&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000045159&_version=1&_urlVersion=0&_userid=835458&md5=62d2ec27df7ce3a645b2c0e2a28dbec3 |
| Field | Biochemistry |
| Keywords | shugoshin; meiosis; separase |
| Description | Shugoshin proteins form a complex with protein phosphatase 2A (PP2A) that protects centromeric cohesin from separase-mediated cleavage during yeast meiosis I. Recent work shows that this mechanism is conserved from yeast to mammals. Importantly, a model emerges that explains a long standing puzzle, namely why the shugoshin PP2A complex mediates protection of centromeric cohesin from separase cleavage specifically during meiosis I, but not during meiosis II or mitosis |