www.rnaworkbench.com: A new program for analyzing RNA interference

• Authors: SVOBODOVÁ VAŘEKOVÁ Radka; BRADÁČ Ivan; PLCHÚT Martin; ŠKRDLA Michal; WACENOVSKY Michael; MAHR Helmuth; MAYER Georg; TANNER Herbert; BRUGGER Hermann; WITHALM Josef; LEDERER Peter; HUBER Heinrich; GIERLINGER Gerhard; GRAF Ronald; TAFER Hakim; HOFACKER Ivo; SCHUSTER Peter; POLCIK Martin
• Year of publication: 2008
• Type: Article in Periodical
• Magazine / Source: Computer Methods and Programs in Biomedicine
• MU Faculty or unit: Faculty of Science
• Field: Physical chemistry and theoretical chemistry
• Keywords: RNA interference; siRNA design; mRNA secondary structures; siRNA sequence rules
• Description: RNA interference (RNAi) has become an important tool to study and utilize gene silencing by introducing short interfering RNA (siRNA). In order to predict the most efficient siRNAs, a new software tool, RNA Workbench (RNAWB), has been designed and is freely available (after registration) on http://www.rnaworkbench.com. In addition to the standard selection rules, RNAWB includes the possibility of statistical analyses of the applied selection rules (criteria). The role of RNA secondary structures in the RNA interference process as well as the application of sequence rules are discussed to show the applicability of the software.

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