Publication details

Overdiagnosis in breast cancer screening programme in the Czech Republic

Authors

BUREŠOVÁ Lucie MÁJEK Ondřej DANEŠ Jan BARTOŇKOVÁ Helena SKOVAJSOVÁ Miroslava DUŠEK Ladislav

Year of publication 2010
Type Appeared in Conference without Proceedings
MU Faculty or unit

Citation
Description Background: There were 1,611,582 examinations performed in 1,067,836 women attending organized breast cancer screening programme in Czech Republic during period 2002-2007. Total of 7,835 cases of breast cancer were detected. Objective: To estimate the extent of overdiagnosis for different age groups. Methods: Overdiagnosis of ductal carcinoma in situ (DCIS) only was assumed. Certain proportion of DCIS is non-progressive and represents the overdiagnosed tumours. Markov models with variable number of states were used. Simultaneous estimation of lambda1 (transition rate to preclinical screen-detectable phase, where no signs of the disease are present, but it could be detected by mammography), lambda2 (transition rate from preclinical screen-detectable phase to clinical phase) and mi (incidence of overdiagnosed tumours) was performed. Estimation procedure was performed using Bayesian methods implemented in WinBUGS software. Results: The incidence of overdiagnosed tumours was from 3 x 10-6 till 9 x 10-6 according to age group examined and was slightly higher for older women. Conclusion: Overdiagnosis doesn’t seem to be significant problem in organized breast cancer screening programme in the Czech Republic.

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