Ecotoxicity and genotoxicity assessment of cytotoxic antineoplastic drugs and their metabolites

• Authors: ZOUNKOVÁ Radka; KOVALOVÁ Lubomíra; BLÁHA Luděk; DOTT Wolfgang
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: Chemosphere
• MU Faculty or unit: Faculty of Science
• Field: Environment influence on health
• Keywords: Cytostatics; Cytotoxic drugs; Metabolites; Ecotoxicity; Cenotoxicity; Chronic effects
• Description: This study reported ecotoxicity and genotoxicity of three widely used cytostatic agents (5-fluorouracil (5-FU), cytarabine (CYT) and gemcitabine (GemC) and their major human metabolites, i.e. alpha-fluoro-beta-alanine (FBAL), uracil-1-beta-D-arabinofuranoside (AraU) and 2',2'-difluorodeoxyuridine (dFdU)).

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