Publication details
Efficient synthesis of ether phosphonates using trichloroacetimidate and acetate coupling methods
| Authors | |
|---|---|
| Year of publication | 2018 |
| Type | Article in Periodical |
| Magazine / Source | RSC ADVANCES |
| MU Faculty or unit | |
| Citation | |
| Web | http://dx.doi.org/10.1039/c8ra00702k |
| Doi | http://dx.doi.org/10.1039/c8ra00702k |
| Keywords | ALPHA-HYDROXYPHOSPHONATES; ACTIVATION; ARYL |
| Description | A series of ether phosphonates have been prepared by trichloroacetimidate and acetate coupling methods. Trichloroacetimidates or acetates were treated with primary and secondary alcohols as O-nucleophiles in the presence of catalytic TMSOTf to afford 21 examples of diethyl alkyloxy(substitutedphenyl)methyl phosphonates via C-O bond formation in 55-90% yields and short reaction time. |