Mgr. Václav Šeda, Ph.D.

2024

• Co-culture with CD40L, IL4 and IL21 expressing stromal cells induces robust CLL cell proliferation in vitro and in PDX co-transplantations

  HOFERKOVÁ Eva FILIP Daniel ONDRIŠOVÁ Laura ŠEDA Václav VERNER Jan MATULOVÁ Květoslava SKUHROVÁ FRANCOVÁ Hana BOUDNÝ Miroslav VEČEŘA Josef KACZ Péter HLAVÁČ Kryštof PAVELKOVÁ Petra KOŠŤÁLOVÁ Lenka MICHAELOU Androniki POSPÍŠILOVÁ Šárka DORAZILOVA Jana DOUBEK Michael VOJTOVA Lucy KŘEN Leoš MAYER Jiří MRÁZ Marek

  Conference abstract

  Year: 2024, type: Conference abstract

• FoxO1/Rictor axis induces a non-genetic adaptation to Ibrutinib via Akt activation in chronic lymphocytic leukemia

  ONDRIŠOVÁ Laura ŠEDA Václav HLAVÁČ Kryštof PAVELKOVÁ Petra HOFERKOVÁ Eva CHIODIN Giorgia KOŠŤÁLOVÁ Lenka MLADONICKÁ PAVLASOVÁ Gabriela FILIP Daniel VEČEŘA Josef FARIA ZENI Pedro OPPELT Jan KAHOUNOVÁ Zuzana VICHOVA Rachel SOUČEK Karel PANOVSKÁ Anna PLEVOVÁ Karla POSPÍŠILOVÁ Šárka ŠIMKOVIČ Martin VRBACKÝ Filip LYSÁK Daniel FERNANDES Stacey M. DAVIDS M.S. MAIQUES-DIAZ Alba CHARALAMPOPOULOU Stella MARTIN-SUBERO Jose I. BROWN Jenifer R. DOUBEK Michael FORCONI Francesco MAYER Jiří MRÁZ Marek

  Article in Periodical

  The Journal of Clinical Investigation, year: 2024, volume: 134, edition: 23, DOI

• MOLECULAR MECHANISM OF NON-GENETIC ADAPTATION TO BTK INHIBITOR THERAPY IN CLL

  ONDRIŠOVÁ Laura ŠEDA Václav HLAVÁČ Kryštof HOFERKOVÁ Eva PAVELKOVÁ Petra KOŠŤÁLOVÁ Lenka FILIP Daniel FARIA ZENI Pedro PANOVSKÁ Anna PLEVOVÁ Karla POSPÍŠILOVÁ Šárka SIMKOVIC M. VRBACKÝ F. LYSÁK Daniel DAVIDS MS. MARTIN-SUBERO JI. BROWN JR. DOUBEK Michael FORCONI Francesco MAYER Jiří MRÁZ Marek

  Conference abstract

  Year: 2024, type: Conference abstract

• STROMAL CELLS ENGINEERED TO EXPRESS T CELL FACTORS INDUCE ROBUST CLL CELL PROLIFERATION IN VITRO AND IN PDX COTRANSPLANTATIONS ALLOWING THE IDENTIFICATION OF ANTI-PROLIFERATIVE DRUGS

  HOFERKOVÁ Eva FILIP Daniel ONDRIŠOVÁ Laura ŠEDA Václav VERNER Jan MATULOVÁ Květoslava SKUHROVÁ FRANCOVÁ Hana BOUDNÝ Miroslav VEČEŘA Josef KACZ Péter HLAVÁČ Kryštof PAVELKOVÁ Petra KOŠŤÁLOVÁ Lenka MICHAELOU Androniki POSPÍŠILOVÁ Šárka DORAZILOVÁ J. DOUBEK Michael VOJTOVÁ Lucy HAMPL Aleš KŘEN Leoš MAYER Jiří MRÁZ Marek

  Conference abstract

  Year: 2024, type: Conference abstract

• Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drug

  HOFERKOVÁ Eva ŠEDA Václav CESNÁRIKOVÁ Soňa VERNER Jan LOJA Tomáš MATULOVÁ Květoslava SKUHROVÁ FRANCOVÁ Hana ONDROUŠKOVÁ Eva FILIP Daniel BLAVET Nicolas BOUDNÝ Miroslav MLADONICKÁ PAVLASOVÁ Gabriela VEČEŘA Josef ONDRIŠOVÁ Laura PAVELKOVÁ Petra HLAVÁČ Kryštof KOŠŤÁLOVÁ Lenka MICHAELOU Androniki POSPÍŠILOVÁ Šárka DORAZILOVÁ Jana CHOCHOLA Václav JAROŠ Josef DOUBEK Michael JAROŠOVÁ Marie HAMPL Aleš VOJTOVÁ Lucy KŘEN Leoš MAYER Jiří MRÁZ Marek

  Article in Periodical

  Leukemia, year: 2024, volume: 38, edition: 8, DOI

2023

• Coculture model with CD40L, IL4 and IL21 for study chronic lymphocytic leukemia proliferation.

  HOFERKOVÁ Eva KADÁKOVÁ Soňa ŠEDA Václav VERNER Jan BOUDNÝ Miroslav MLADONICKÁ PAVLASOVÁ Gabriela LOJA Tomáš FILIP Daniel VEČEŘA Josef MATULOVÁ Květoslava SKUHROVÁ FRANCOVÁ Hana SHARMA Sonali ONDRIŠOVÁ Laura PALUŠOVÁ Veronika VOJTOVÁ Lucy KŘEN Leoš DOUBEK Michael MRÁZ Marek

  Conference abstract

  Year: 2023, type: Conference abstract

• FOX01-rictor AXIS induces AKT phosporylation during CLL cell adaptation to BCR inhibitors: Implications for combinatorial therapy.

  ONDRIŠOVÁ Laura ŠEDA Václav HOFERKOVÁ Eva CHIODIN G. HLAVÁČ Kryštof KOŠŤÁLOVÁ Lenka MLADONICKÁ PAVLASOVÁ Gabriela FILIP Daniel FARIA ZENI Pedro OPPELT Jan PANOVSKÁ Anna PLEVOVÁ Karla POSPÍŠILOVÁ Šárka SIMKOVIC M. VRBACKÝ F. LYSÁK Daniel FERNANDES SM. DAVIDS MS. MAIQUES-DIAZ A. CHARALAMPOPOULOU S. MARTIN-SUBERO JI. BROWN JR. DOUBEK Michael FORCONI F. MAYER Jiří MRÁZ Marek

  Conference abstract

  Year: 2023, type: Conference abstract

• FOXO1-RICTOR AXIS induces adaptive increase in AKT activity during BCR inhibitor therapy in CLL: Implications for combination therapy.

  ONDRIŠOVÁ Laura ŠEDA Václav CHIODIN Giorgia HLAVÁČ Kryštof KOŠŤÁLOVÁ Lenka FILIP Daniel FARIA ZENI Pedro PANOVSKÁ Anna PLEVOVÁ Karla POSPÍŠILOVÁ Šárka ŠIMKOVIČ Martin VRBACKÝ Filip LYSÁK Daniel FERNANDEZ Stacey M. DAVIDS MS. MAIQUES-DIAZ Alba CHARALAMPOPOULOU Stella MARTIN-SUBERO Jose I. BROWN Jennifer R. DOUBEK Michael FORCONI Francesco MAYER Jiří MRÁZ Marek

  Conference abstract

  Year: 2023, type: Conference abstract

• Foxo1-Rictor axis mediates adaptive increase in Akt activity and cell survival during BCR inhibitor therapy in chronic lymphocytic leukemia.

  HLAVÁČ Kryštof ONDRIŠOVÁ Laura ŠEDA Václav HOFERKOVÁ Eva CHIODIN G. KOŠŤÁLOVÁ Lenka MLADONICKÁ PAVLASOVÁ Gabriela FILIP Daniel FARIA ZENI Pedro OPPELT Jan PANOVSKÁ Anna PLEVOVÁ Karla POSPÍŠILOVÁ Šárka ŠIMKOVIČ M. VRBACKÝ F. LYSÁK Daniel FERNANDES SM. DAVIDS MS. MAIQUES-DIAZ A. CHARALAMPOPOULOU S. MARTIN-SUBERO I. BROWN JR. DOUBEK Michael FORCONI Francesco MAYER Jiří MRÁZ Marek

  Conference abstract

  Year: 2023, type: Conference abstract

• Inhibitors for treatment of hematological malignancies

  MRÁZ Marek ŠEDA Václav ONDRIŠOVÁ Laura

  Patent

  Publisher: United States Patent and Trademark Office, state: United States of America, patent's number: US11648255B2, year: 2023