Publication details

HLA alleles in autoimmune diabetes mellitus with onset after 35 year

Authors

ČERNÁ Marie ČEJKOVÁ M. AMBROŠOVÁ Petronela KUKLÍNEK Pavel MELUZÍNOVÁ Hana POLCAROVÁ Vlasta WEBER Pavel

Year of publication 2011
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description We summarize that in the Central Bohemian population of the Czech Republic, the INS –23HphI A allele appears to be associated with a decrease in pancreatic beta cell secretory activity. HLA genotyping points to at least a partial difference in mechanism, which leads to T1DM and LADA development as well as a more diverse genetic predisposition in juvenile- and adult-onset diabetes. The simultaneous effect of HLA and INS-VNTR alleles/ genotypes predispose individuals to an increased risk of diabetes development.

You are running an old browser version. We recommend updating your browser to its latest version.

More info