Publication details

MicroRNAs targeting EGFR signalling pathway in colorectal cancer

Authors

MLČOCHOVÁ Jitka FALTEJSKOVÁ Petra NĚMEČEK Radim SVOBODA Marek SLABÝ Ondřej

Year of publication 2013
Type Article in Periodical
Magazine / Source Journal of cancer research and clinical oncology
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://link.springer.com/article/10.1007%2Fs00432-013-1470-9
Doi http://dx.doi.org/10.1007/s00432-013-1470-9
Field Oncology and hematology
Keywords MicroRNA; Colorectal cancer; EGFR signalling pathway; Predictive biomarkers; Prognostic biomarkers
Description MicroRNAs (miRNAs) are short, 18–25- nucleotide long, non-coding single-stranded RNAs, which are capable to regulate gene expression on post-transcrip- tional level through binding to their target protein-encoding mRNAs. miRNAs regulate individual components of multiple oncogenic pathways. One of them is epidermal growth factor receptor (EGFR) signalling pathway that regulates cell proliferation, differentiation, migration, angiogenesis and apoptosis. All these processes are deregulated in colorectal cancer (CRC). Moreover, EGFR has been validated as the therapeutic target in CRC, and monoclonal antibodies cetuximab and panitumumab are used in the therapy of patients with metastatic CRC. Because of the extensive involvement of miRNAs in the regulation of EGFR signalling, it seems they could also serve as promising predictive biomarkers to anti-EGFR therapy. In this review, we summarize current knowledge about miRNAs targeting EGFR signalling pathway, their functioning in CRC pathogenesis and potential usage as biomarkers.
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