Publication details
Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
| Authors | |
|---|---|
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Journal of Hematology & Oncology |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.jhoonline.org/content/6/1/42 |
| Doi | http://dx.doi.org/10.1186/1756-8722-6-42 |
| Field | Oncology and hematology |
| Keywords | Platelet; PF-4; CTAP-III; Cancer; Angiogenesis; IL-8; Inflammation |
| Description | With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers. |