Publication details

The miR-29 family in hematological malignancies

Authors

FIŠEROVÁ Barbora BEŠŠE Lenka SEDLAŘÍKOVÁ Lenka HÁJEK Roman ŠEVČÍKOVÁ Sabina

Year of publication 2015
Type Article in Periodical
Magazine / Source Biomedical Papers
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.5507/bp.2014.037
Field Oncology and hematology
Keywords microRNA; miR-29 family; hematological malignancy; circulating miRNA
Description Background. MicroRNAs are short non-coding regulators of gene expression. The human miR-29 family consists of three members: miR-29a, miR-29b and miR-29c. Members of this family were found to be aberrantly expressed in various types of tumors, including hematological malignancies. This family was described to have both oncogenic and tumor suppressor features influencing various pathological processes, such as tumor growth and apoptosis. This review summarizes current knowledge about the miR-29 family in selected hematological malignancies. Conclusion. Recent research of miR-29 family in hematological malignancies has proven its oncogenic as well as tumor suppressive potential. Nevertheless, the level of current evidence is not sufficient, and data remain inconclusive.
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