Publication details

Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension

Authors

MELUZÍN Jaroslav KÁRA Tomáš BELEHRAD Milos STÁREK Zdeněk STEPANOVA Radka MIKUŠOVÁ Tereza PODROUŽKOVÁ Helena ŠPINAROVÁ Monika SOUCEK Miroslav SOŠKA Vladimír

Year of publication 2014
Type Article in Periodical
Magazine / Source Experimental and Clinical Cardiology
MU Faculty or unit

Faculty of Medicine

Citation
Field Cardiovascular diseases incl. cardiosurgery
Keywords Diastolic dysfunction; Heart failure; Sleep apnea
Description Objectives: The aim of this study was to assess the relationship of the severity of myocardial dysfunction to the severity of sleep apnea syndrome (SAS) in patients with drug-resistant hypertension. Methods and Results: Thirty-five patients with drug-resistant hypertension underwent complete overnight polysomnography and comprehensive echocardiography including Doppler tissue imaging and speckle tracking analysis within 24 hours. Severe SAS was defined by the presence of severe SA-induced hypoxemia as indicated by percentage of sleep time with oxygen saturation < 90% (t90)>/= 12%. Heart failure with normal ejection fraction (HFNEF) and t90 >/= 12% were found in 66% and 31% of subjects, respectively. Multivariate regression analysis revealed a significant and independent association of left atrial volume index (LAVI) with t90 >/= 12% (OR 1.292, CI 1.041-1.604, p = 0.020). Severe SA-induced hypoxemia was found in 11 (48%) patients with HFNEF, but in none of those without HFNEF (p < 0.01). Conclusion: In patients with drug-resistant hypertension, there exists a significant association of diastolic dysfunction and heart failure with severe SAS. LAVI represents an independent predictor of severe SA-induced hypoxemia.

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