Publication details
MECHANISM OF BASE EXCISION WITH THE hOGG1 DNA REPAIR ENZYME
| Authors | |
|---|---|
| Year of publication | 2014 |
| Type | Article in Periodical |
| Magazine / Source | Chemické listy |
| MU Faculty or unit | |
| Citation | |
| Web | http://chemicke-listy.cz/docs/full/2014_04_364-367.pdf |
| Field | Biochemistry |
| Keywords | NUCLEIC-ACID BASES; GLYCOSIDIC BOND-CLEAVAGE; HUMAN 8-OXOGUANINE GLYCOSYLASE; AB-INITIO; TRANSITION-STATE; PROTEIN HOGG1; HARTREE-FOCK; OGG1 GENE; RECOGNITION; GUANINE |
| Description | This article suggests a new mechanistic scheme of the catalytic 8-oxoguanine excision with the hOGG1 base excision repair protein. The energy-efficient and substrate-specific scheme employs enforced pyramidalization of the glycosidic nitrogen in the nucleobase within the hOGG1 catalytic pocket. |
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