Publication details
Intelektový výkon dětí matek s tyreopatií v těhotenství (první výsledky výzkumu)
| Title in English | Intellectual performance of children of mothers with thyroid disease in pregnancy (first results of research) |
|---|---|
| Authors | |
| Year of publication | 2014 |
| Type | Article in Periodical |
| Magazine / Source | Postgraduální medicína : odborný časopis pro lékaře |
| MU Faculty or unit | |
| Citation | |
| Field | Psychology |
| Keywords | intellect; pregnancy; thyrotropin; antibodies against thyroid peroxidase |
| Attached files | |
| Description | The link between impaired neurodevelopment and thyroid dysfunction after birth has been well-known for more than 100 years. But only in the late 20th century the importance of thyroid hormones for fetus during pregnancy was confirmed. It took another 10 years to come to agreement about the importance of thyroid hormones for the development of a child in the second and third trimester of pregnancy. Whether maternal thyroid dysfunction has negative impact on the fetus development in the first trimester of pregnancy, when the fetus is utterly dependent on maternal thyroid hormones, is unknown. Between 2004 and 2006, thyroid function tests were gathered in 1649 pregnant women of the Havlíčkův Brod area. Eight years after this screening begun, we assessed intellectual performance in 267 children of women from the screening. Consequent selection provided a group of 74 children of women with untreated thyroid dysfunction in the first trimester of pregnancy (TSH higher or equal 3,5 and/or TPO-Ab higher or equal 20). We compared the results with a control group of 132 children. We found no significant difference between the results of intellectual function in the group of children of mothers with untreated thyroid dysfunction in the first trimester of pregnancy and the control group. The intellectual function of children in both groups was around average, i.e. within the normal distribution in population. |