Publication details

DNA, the central molecule of aging

Authors

LÉNÁRT Peter KREJČÍ Lumír

Year of publication 2016
Type Article in Periodical
Magazine / Source Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1016/j.mrfmmm.2016.01.007
Field Genetics and molecular biology
Keywords DNA; Aging; Chromatin structure; Telomeres; DNA damage; DNA repair; Mutagenesis
Description Understanding the molecular mechanism of aging could have enormous medical implications. Despite a century of research, however, there is no universally accepted theory regarding the molecular basis of aging. On the other hand, there is plentiful evidence suggesting that DNA constitutes the central molecule in this process. Here, we review the roles of chromatin structure, DNA damage, and shortening of telomeres in aging and propose a hypothesis for how their interplay leads to aging phenotypes.
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