Publication details

Uterine Fibroid Morphology and Histology with Respect to Reproductive Age

Authors

HUDEČEK Robert HUSER Martin JANDÁKOVÁ Eva MEKIŇOVÁ Lenka KADLECOVÁ Jana VENTRUBA Pavel

Year of publication 2016
Type Article in Periodical
Magazine / Source The Journal of Reproductive Medicine
MU Faculty or unit

Faculty of Medicine

Citation
Field Gynaecology and obstetrics
Keywords fibroid; fibroid tumor; fibroid uterus; fibroma uterine; gynecologic surgical procedures; histology; leiomyoma; uetrine fibroid; uterine myomestomy
Description OBJECTIVE: To evaluate histological uterine fibroid incidence among reproductive age women and to determine correlations between fibroid histological type, patient age, and number and size of fibroids. STUDY DESIGN: The study cohort consisted of 103 women desiring pregnancy who underwent myomectomy for symptomatic uterine fibroids. The primary endpoints were histological type of fibroid, myomectomy incidence among 2 age groups (18-34 vs. 35-40), solitary or multiple fibroids, and <5 cm vs. >5 cm fibroid diameter. Secondary analysis endpoints evaluated correlations between uterine fibroid histological type, 2 age groups of women, and uterine fibroid number and size. RESULTS: Following myomectomy, 84.5% exhibited benign histology, and myomatosis malignancy was not detected. Of the 103 women, 50.5% were aged <34 and 49.5% were aged 35-40; 71.8% had a solitary fibroid and 28.2% had a >= 2 fibroids; 58.3% had a fibroid of <5 cm and 41.7% had a fibroid >5 cm in diameter. Cellular fibroid incidence was higher (10.3%) in cases of multiple myomatosis in comparison to the solitary fibroid group (n=0) (p=0.021). Among women with multiple myomatosis (n=29), almost all (n=28, 96.6%) had only 1 histological type. CONCLUSION: Among women of child-bearing age having myomectomy, most have benign histology with no significant differences in histological type with regard to patient age and fibroid size. A higher incidence of cellular fibroids was observed only in multiple myomatosis cases.

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