Publication details

Pomalidomid v léčbě mnohočetného myelomu vlastní zkušenosti a přehled literatury

Title in English Pomalidomide in the treatment of multiple myeloma - own experience and overview of literature
Authors

ADAM Zdeněk POUR Luděk KREJČÍ Marta VETEŠNÍKOVÁ Eva SANDECKÁ Viera ŠTORK Martin ČERMÁKOVÁ Zdeňka POUROVÁ Eva ŠEVČÍKOVÁ Sabina KRÁL Zdeněk MAYER Jiří

Year of publication 2016
Type Article in Periodical
Magazine / Source Vnitřní lékařství
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords lenalidomide; multiple myeloma; pomalidomide; thalidomide
Description In the Czech Republic, pomalidomide is covered for patients with multiple myeloma (in combination with dexa-methasone), in the treatment of patients with relapsed and refractory multiple myeloma, who underwent at least 2 previous treatment schedules including both lenalidomide and bortezomibe, with disease progression despite the last therapy (i.e. during the therapy or within 60 days of its end), for whom the only remaining alternative of treatment (apart from pomalidomide) is that using high-dose dexamethasone, and who are not indicated for mye-loablative treatment followed by a transplant of stem cells. At our centre pomalidomide was used in 53 patients at a median age of 66 years based on this indication. Pomalidomide was administered in 1 daily dose over 21 days in 28-day cycles. Considering the risk of thromboembolism occurring in this therapy, all patients were administered a prophylactic dose of low-molecular-weight heparin. No patient achieved complete remission (Czech Republic), 5 patients (9.4 %) achieved very good partial remission (VGPR), partial remission (PR) was achieved by 16 (30.2 %) patients, a minimum therapeutic response (MR) was recorded for 6 (11.3 %) patients. The median number of administered cycles was 4.4 (1-22). 16 (28.5 %) patients received treatment for more than 6 months. The overall survival median cannot be evaluated so far due to a short follow-up period. Nonetheless it was possible to evaluate a median time interval to progression (TTP) for the patients, which amounted to 7.0 (3.8-8.2) months.

You are running an old browser version. We recommend updating your browser to its latest version.

More info