Publication details

Trombofilní stavy v těhotenství

Title in English Thrombophilic conditions during pregnancy


Year of publication 2016
Type Article in Periodical
Magazine / Source Anesteziologie a intenzivní medicína
MU Faculty or unit

Faculty of Medicine

Field Other medical specializations
Keywords pregnancy; thrombophilia; prophylaxis; anaesthetic managemenent
Description The risk of venous thromboembolic events is high during pregnancy due to both physiologic changes of pregnancy and the additional impact of the inherited and acquired thrombophilias. The women with thrombophilia are at increased risk, not only of pregnancy-related venous thromboembolism (VTE), but also other pregnancy complications, including early and late pregnancy loss, intrauterine growth restriction, placental abruption, and pre-eclampsia. Depending on the type of thrombophilia, personal and family history of VTE and history of pregnancy complications prophylactic treatment with low molecular weight heparin or unfractionated heparin is recommended. For women with thrombophilia and history of pregnancy complications combination of low dose aspirin and heparin can increase probability of live birth. On the other hand, pregnant women on prophylactic or therapeutic anticoagulation require an individualized delivery plan that addresses obstetrical, anesthetic, and thrombotic concerns.

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