Publication details

Lack of Association between BMP2/DLX3 Gene Polymorphisms and Dental Caries in Primary and Permanent Dentitions

Authors

KAŠTOVSKÝ Jakub BOŘILOVÁ LINHARTOVÁ Petra MUSILOVÁ Kristína ŽÁČKOVÁ Lenka KUKLETOVÁ Martina KUKLA Lubomír IZAKOVIČOVÁ HOLLÁ Lydie

Year of publication 2017
Type Article in Periodical
Magazine / Source Caries Research
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1159/000479828
Field ORL, ophthalmology, stomatology
Keywords BMP2; Case-control study; Dental caries; DLX3; Gene polymorphism
Description The aim of this study was to analyze the association between BMP2 (rs1884302) and DLX3 (rs2278163) gene polymorphisms and dental caries in primary and permanent dentitions. A total of 914 subjects were genotyped by the TaqMan methods: 176 caries-free children (with Decayed/Missing/Filled Teeth, DMFT = 0), 542 patients with dental caries in permanent dentition (DMFT >/= 1), 83 caries-free children with primary teeth (with decayed/missing/filled teeth, dmft = 0), and 113 children with early childhood caries (ECC, dmft >/= 1). There were no significant differences in allele/genotype frequencies between patients with caries in permanent dentition/ECC and caries-free children or between patients with very low (DMFT = 0-2), low (DMFT = 3-5), moderate (DMFT = 6-8), or high (DMFT >/= 9) caries experience. Variability in BMP2 and DLX3 was not associated with caries in the Czech population.
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