Publication details
A draft of bronchoscopic grading system in patients with toxic epidermal necrolysis
| Authors | |
|---|---|
| Year of publication | 2017 |
| Type | Article in Periodical |
| Magazine / Source | Burns |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1016/j.burns.2017.01.005 |
| Field | Surgery incl. transplantology |
| Keywords | toxic epidermal necrolysis |
| Description | Toxic epidermal necrolysis (TEN) is a rare, life-threatening condition, which is caused by the development of massive apoptosis in the dermoepidermal junction [1]. This apoptosis is mainly caused by caspase mechanisms, which are affected by the activity of T-lymphocytes (CD4+ and CD8+), NK cells, or the bond of CD95L to CD95R [2]. Noncaspase mechanisms are also applied in the TEN pathophysiology, e.g., production of granzyme B CD8+ T lymphocytes or NK cells. |