Publication details

Dioxin-like compounds bioavailability and genotoxicity assessment in the Gulf of Follonica, Tuscany (Northern Tyrrhenian Sea)


GUIDI Patrizia CORSOLINI Simonetta BERNARDESCHI Margherita ROCCO Lucia NIGRO Marco BARONI Davide MOTTOLA Filomena SCARCELLI Vittoria SANTONASTASO Marianna FALLENI Alessandra DELLA TORRE Camilla CORSI Ilaria POZO Karla Andrea FRENZILLI Giada

Year of publication 2018
Type Article in Periodical
MU Faculty or unit

Faculty of Science

Keywords DNA damage; RAPD-PCR; Cytome-Micronucleus assay; PCDDs/DFs; TEQs; PCBs
Description The Gulf of Follonica (Italy) is impacted by the chemical pollution from ancient mining activity and present industrial processes. This study was aimed to determine the bioavailability of dioxin-like compounds (DLCs) in coastal marine environment and to assess the genotoxic potential of waste waters entering the sea from an industrial canal. Moderately high levels of DCLs compounds (ZPCDDs + PCDFs 2.18-29.00 pg/g dry wt) were detected in Mytilus galloprovincialis transplanted near the waste waters canal and their corresponding Toxic Equivalents (TEQs) calculated. In situ exposed mussels did not show any genotoxic effect (by Comet and Micronucleus assay). Otherwise, laboratory exposure to canal waters exhibited a reduced genomic template stability (by RAPD-PCR assay) but not DNA or chromosomal damage. Our data reveal the need to focus on the levels and distribution of DLCs in edible species from the study area considering their potential transfer to humans through the consumption of sea food.

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