AC Pulsed Field Ablation Is Feasible and Safe in Atrial and Ventricular Settings: A Proof-of-Concept Chronic Animal Study

• Authors: CALUORI Guido; ODEHNALOVÁ Eva; JADCZYK Tomasz; PEŠL Martin; PAVLOVÁ Iveta; VALÍKOVÁ Lucia; HOLZINGER Steffen; NOVOTNÁ Veronika; ROTREKL Vladimír; HAMPL Aleš; CRHA Michal; ČERVINKA Dalibor; STÁREK Zdeněk
• Year of publication: 2020
• Type: Article in Periodical
• Magazine / Source: Frontiers in bioengineering and biotechnology
• MU Faculty or unit: Faculty of Medicine
• web: https://www.frontiersin.org/articles/10.3389/fbioe.2020.552357/full
• Doi: https://doi.org/10.3389/fbioe.2020.552357
• Keywords: pulsed field ablation; irreversible electroporation (IRE); radiofrequency ablation; atrial fibrillation; ventricular arrhythmia (VA); preclinical cardiology
• Description: Pulsed field ablation (PFA) exploits the delivery of short high-voltage shocks to induce cells death via irreversible electroporation. The therapy offers a potential paradigm shift for catheter ablation of cardiac arrhythmia. We designed an AC-burst generator and therapeutic strategy, based on the existing knowledge between efficacy and safety among different pulses. We performed a proof-of-concept chronic animal trial to test the feasibility and safety of our method and technology.