Publication details

Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis

Authors

SKOPALOVÁ Kateřina RADASZKIEWICZ Katarzyna Anna KAŠPÁRKOVÁ Věra STEJSKAL Jaroslav BOBER Patrycja JUNKAR Ita MOZETIC Miran CAPÁKOVÁ Zdenka LEHOCKÝ Marián KAŠPAROVÁ Martina PACHERNÍK Jiří HUMPOLÍČEK Petr

Year of publication 2021
Type Article in Periodical
Magazine / Source International Journal of Molecular Sciences
MU Faculty or unit

Faculty of Science

Citation
Web https://doi.org/10.3390/ijms22020501
Doi http://dx.doi.org/10.3390/ijms22020501
Keywords conducting polymer; polypyrrole; biocompatibility; neurogenesis; stem cells
Description The active role of biomaterials in the regeneration of tissues and their ability to modulate the behavior of stem cells in terms of their differentiation is highly advantageous. Here, polypyrrole, as a representantive of electro-conducting materials, is found to modulate the behavior of embryonic stem cells. Concretely, the aqueous extracts of polypyrrole induce neurogenesis within embryonic bodies formed from embryonic stem cells. This finding ledto an effort to determine the physiological cascade which is responsible for this effect. The polypyrrole modulates signaling pathways of Akt and ERK kinase through their phosphorylation. These effects are related to the presence of low-molecular-weight compounds present in aqueous polypyrrole extracts, determined by mass spectroscopy. The results show that consequences related to the modulation of stem cell differentiation must also be taken into account when polypyrrole is considered as a biomaterial.
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