Publication details
Mozková perfuze a deprese-99mTc-HMPAO SPECT
| Title in English | Brain Perfusion and Depression-99mTc-HMPAO SPECT |
|---|---|
| Authors | |
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | Psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Psychiatry, sexuology |
| Keywords | depression; treatment; brain perfusion; SPECT |
| Description | The authors investigated regional brain perfusion in 33 depressive patients and 15 patient without any symptoms presence of depressive syndrome and who served as control group. The perfusion was measured by single photon emission computed tomography (SPECT). There was no significant difference in basal perfusion between depressive group and controls. In complete responders (HAMD less than 7 points after treatment) perfusion significantly increased in the frontal lobe, the basal ganglia and the lateral parts of temporal lobes. In nonresponders perfusion decreased conversely. Treatment reactivity was associated with brain perfusion changes. These changes are considered to be a state marker of depression. Our results show the brain perfusion metering in depressive patients by the method SPECT can have meaning for the objective appreciation of the reactivity on treatments. |
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