Publication details

Combination of drugs elevating extracellular adenosine with granulocyte colony-stimulating factor promotes granulopoietic recovery in the murine bone marrow after 5-fluorouracil treatment

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Authors

HOFER Michal POSPÍŠIL Milan WEITEROVÁ Lenka ZNOJIL Vladimír VÁCHA Jiří HOLÁ Jarmila VACEK Antonín PIPALOVÁ Iva

Year of publication 2001
Type Article in Periodical
Magazine / Source Physiological Research
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Description Combined administration of drugs elevating extracellular adenosine, namely dipyridamole and adenosine monophosphate, together with granulocyte colony-stimulating factor was shown to enhance granulopoietic recovery in the bone marrow of mice treated with 5-fluorouracil. The results might have positive clinical impact. The adjunct use of drugs elevating extracellular adenosine might reduce the cost expenditure of therapy with granulocyte colony-stimulating factor.
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