Publication details

Changes in the cytoskeleton of P19 cells during apoptosis associated with induced differentiation

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Authors

NERADIL Jakub VESELSKÁ Renata SVOBODA Augustin

Year of publication 2002
Type Article in Proceedings
Conference Cells IV
MU Faculty or unit

Faculty of Medicine

Citation
Field Morphological specializations and cytology
Keywords induced differentiation; apoptosis; cytoskeleton; P19 cell line; retinoic acid; dimethylsulfoxide; actin filaments; microtubules
Description The aim of the work was to study the morphology of microtubules and actin filaments during the apoptosis accompanying the differentiation of P19 cells. Mesodermal differentiation was induced by dimtehylsulfoxide and retinoic acid was used for induction of neuronal differentiation. To summarize, actin cytoskeleton actively participates in the executive phase of apoptosis whereas microtubules are only passively degraded in consequence of tubulin proteolysis.
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