Publication details

Effects of endocannabinoids on agonistic behaviour in mice

Authors

NOVÁKOVÁ Jana VINKLEROVÁ Jana ŠULCOVÁ Alexandra

Year of publication 2002
Type Article in Periodical
Magazine / Source Adiktologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords CB1 and CB2 cannabinoid receptor subtypes; endocannabinoids; agonistic behaviour; mice
Description The present study was designed to ascertain behavioural effects of novel endocannabinoid ligand noladin ether using the model of agonistic behaviour in mice. In aggressive singly-housed mice, noladin did not show marked changes in behavioural activities. The only significant effect recorded was the significant inhibition of sociable sniffing. In timid isolates, noladin elicited a significant aggresssogenic action with the impairment of the locomotor activity. Thus, the behavioural noladin profile found did not fully resemble that of anandamide which in our earlier experiments exerted a significant antiaggressive effects using the model of mouse agonistic social interactions.
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