Publication details

Diagnostika kostních mikrometastáz u malobuněčné formy plicního karcinomu - první výsledky

Title in English Diagnosis of bone micrometastases in non-small cell lung carcinoma--initial results
Authors

ČAPOV Ivan WECHSLER Jan JEDLIČKA Václav PEŠTÁL Adam ŠÍPKOVÁ Renata REJTHAR Aleš KRPENSKÝ Antonín LŽIČAŘOVÁ Eva

Year of publication 2003
Type Article in Periodical
Magazine / Source Rozhledy v chirurgii
MU Faculty or unit

Faculty of Medicine

Citation
Field Surgery incl. transplantology
Keywords bone micrometastases; cytokeratin; non-small cell lung cancer
Description The objective was to elaborate a method of immunohistochemical diagnosis of bone micrometastases and to apply this procedure in operated patients with the non-small cell form of lung cancer. By means of a cocktail of cytokeratin mixtures and individual cytokeratins the immunohistochemical profile of the primary pulmonary focus is assessed. Bone micrometastases are evaluated from the bone marrow of a sampled costal segment. A total of 30 bone marrow samples were examined. For further evaluation 17 patients remained in the group. Isolated segments with a marked positivity of cytokeratins were observed in four instances. The yield of bone marrow from costal segment is very good. The initial results are encouraging for further research.
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