Publication details

Platinum(V) Complex with Adamantylamine as Nonleaving Amine Group: Synthesis, Characterization, and in Vitro Antitumor Activity against a Panel of Cisplatin-Resistant Cancer Cell Lines

Authors

ŽÁK František TURÁNEK Jaroslav KROUTIL Aleš SOVA Petr MISTR Adolf POULOVÁ Anna MIKOLIN Petr ŽÁK Zdirad KAŠNÁ Andrea ZÁLUSKÁ Dana NEČA Jiří ŠINDLEROVÁ Lenka KOZUBÍK Alois

Year of publication 2004
Type Article in Periodical
Magazine / Source Journal Medicinal Chemistry
MU Faculty or unit

Faculty of Science

Citation
Field Immunology
Keywords Platinum(V) Complex with Adamantylamine as Nonleaving Amine Group
Description Procedure of the synthesis is dedescribed for new platinum(V) drug LA-12 [(OC-6-43)-bis-(acetato)(1-adamantylamine)amminedichloroplatinum(IV)]. The X-ray diffraction analysis shows that the structure is created by molecules with octahedral arrangement of ligands around a platinum atom and contains one H2O molecule that is not a part of the coordination sphere of platinum.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info