Synthesis and tautomerism study of 7-substituted pyrazolo[3,4-c]pyridines

• Authors: KOURAFALOS Vassilios N.; MARAKOS Panagiotis; MIKROS Emmanuel; POULI Nicole; MAREK Jaromír; MAREK Radek
• Year of publication: 2006
• Type: Article in Periodical
• Magazine / Source: Tetrahedron
• MU Faculty or unit: Faculty of Science
• Web: http://www.sciencedirect.com/science/journal/00404020
• Field: Organic chemistry
• Keywords: pyrazolo[3;4-c]pyridine; tautomerism; NMR spectroscopy; X-ray diffraction
• Description: A number of 7-substituted pyrazolo[3,4-c]pyridine derivatives have been synthesized in order to investigate the N1–N2 tautomerism within this class of biologically interesting compounds. Tautomeric equilibrium has been studied using NMR 13C, 15N chemical shifts and heteronuclear 1H–15N and 1H–13C spin–spin couplings, in conjunction with X-ray crystallography. The N1 tautomer predominates in DMF solution in all the compounds tested.

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