Publication details

Synthesis and tautomerism study of 7-substituted pyrazolo[3,4-c]pyridines


KOURAFALOS Vassilios N. MARAKOS Panagiotis MIKROS Emmanuel POULI Nicole MAREK Jaromír MAREK Radek

Year of publication 2006
Type Article in Periodical
Magazine / Source Tetrahedron
MU Faculty or unit

Faculty of Science

Field Organic chemistry
Keywords pyrazolo[3;4-c]pyridine; tautomerism; NMR spectroscopy; X-ray diffraction
Description A number of 7-substituted pyrazolo[3,4-c]pyridine derivatives have been synthesized in order to investigate the N1–N2 tautomerism within this class of biologically interesting compounds. Tautomeric equilibrium has been studied using NMR 13C, 15N chemical shifts and heteronuclear 1H–15N and 1H–13C spin–spin couplings, in conjunction with X-ray crystallography. The N1 tautomer predominates in DMF solution in all the compounds tested.
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